منابع مشابه
Protease inhibitors as antiviral agents.
Currently, there are a number of approved antiviral agents for use in the treatment of viral infections. However, many instances exist in which the use of a second antiviral agent would be beneficial because it would allow the option of either an alternative or a combination therapeutic approach. Accordingly, virus-encoded proteases have emerged as new targets for antiviral intervention. Molecu...
متن کاملNon-Peptide Protease Inhibitors as Novel AntiHIV Agents
The human immunodeficiency virus has been shown to be the causative agent for acquired immunodeficiency syndrome (AIDS). The human immunodeficiency virus encodes for unique aspartyl protease that is essential for the production of enzymes and proteins in the final stages of maturation. Protease inhibitors act by preventing the formation of functional proteins from precursor proteins, which are ...
متن کاملIn vitro antiviral interaction of lopinavir with other protease inhibitors.
The in vitro inhibition of wild-type human immunodeficiency virus (HIV) by combinations of lopinavir and six other protease inhibitors over a range of two-drug combination ratios was evaluated. Combinations of lopinavir with indinavir, nelfinavir, amprenavir, tipranavir, and BMS-232632 generally displayed an additive relationship. In contrast, a consistent, statistically significant synergistic...
متن کاملCyclotides Enhance the Antiviral Effects of Hiv-1 Protease Inhibitors
The development of HIV-1 protease inhibitors (HPIs) in highly active antiretroviral therapy (HAART) has dramatically decreased AIDS mortality. However, HPIs exhibit suboptimal therapeutics in vivo due to their intrinsic low oral absorption and rapid efflux via ATP-binding cassette transporters. These attributes facilitate uninhibited viral propagation and rapid selection of drug resistant HIV-1...
متن کاملSubstituted 3-benzylcoumarins as allosteric MEK1 inhibitors: design, synthesis and biological evaluation as antiviral agents.
In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized. Based on docking results, multiple optimizations were made on the coumarin scaffold. Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed obvious inhibitory effects on the ERK pathway in a cellular assay. These compounds also ...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 1998
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.11.4.614